Lusine Zakaryan, born Svetlana Zakaryan (1 June 1937, Akhaltsikhe, Georgian SSR – 30 December 1991), was an Armenian soprano. Zakaryan grew up in the Samtskhe-Javakheti region of southern Georgia.
In 1952, Zakaryan moved with her family to Yerevan, where she attended a secondary music school. Zakaryan entered the Yerevan State Musical Conservatory in 1957 and her singing talent soon became clear.
From 1970 to 1983, Zakaryan was a soloist with the symphony orchestra of Armenian TV and Radio. Zakaryan also sang in the choir of the Armenian Apostolic Church's Holy See at the Echmiadzin Cathedral, and it is for her magnificent rendition of centuries-old Armenian spiritual hymns that she is now most remembered.
Zakaryan was also known for singing the international opera repertoire as well as Armenian traditional and church music.